Our group is interested in brain network analysis in neurological disorders, with a particular focus in epilepsy. Knowledge of brain network abnormalities in epilepsy will help us better understand the behavioral and cognitive effects of seizures over time, and may lead to better treatments, including surgical procedures and neuromodulation.
Currently, we are using human neuroimaging and electrophysiology to examine both resting-state and dynamic connectivity disturbances in epilepsy and other neurological disorders. This includes analysis of subcortical networks involved in arousal, as well as those relevant to surgical outcome.
Englot DJ, D Haese PF, Konrad PE, Jacobs ML, Gore JC, Abou-Khalil BW, Morgan VL (2017) Functional connectivity disturbances of the ascending reticular activating system in temporal lobe epilepsy. J Neurol Neurosurg Psychiatry: in press.
Englot DJ, Hinkley LB, Kort NS, Imber BS, Mizuiri D, Honma SM, Findlay AM, Garrett C, Cheung PL, Mantle M, Tarapore PE, Knowlton RC, Chang EF, Kirsch HE, Nagarajan SS (2015) Global and regional functional connectivity maps of neural oscillations in focal epilepsy. Brain 138(8):2249-62.
Englot DJ, Yang L, Hamid H, Danielson N, Bai X, Marfeo A, Yu L, Gordon A, Purcaro MJ, Motelow JE, Agarwal R, Ellens DJ, Golomb JD, Shamy MCF, Zhang H, Carlson C, Doyle W, Devinsky O, Vives K, Spencer DD, Spencer SS, Schevon C, Zaveri HP, Blumenfeld H (2010) Impaired consciousness in temporal lobe seizures: role of cortical activity. Brain 133(12):3764-77.
Englot DJ, Modi B, Mishra AM, DeSalvo M, Hyder F, Blumenfeld H (2009) Cortical deactivation induced by subcortical network dysfunction in limbic seizures. J Neurosci 29(14):13006-18.
Englot DJ, Mishra AM, Mansuripur PK, Herman P, Hyder F, Blumenfeld H (2008) Remote effects of focal hippocampal seizures on the rat neocortex. J Neurosci 28(36):9066-81.