I am interested in using neuroimaging to identify differences in cerebrovascular function in middle-aged adults at genetic risk for Alzheimer's disease. I also use cognitive testing to see what affect cerebrovascular health might have on cognition.
My project is identifying physiological and cognitive changes taking place in middle-aged adults at genetic risk for Alzheimer's disease compared to people that are not at genetic risk. Arterial spin labeling and magnetic resonance angiography will be used to understand how factors such as cerebral blood flow, cerebrovascular reactivity, bolus arrival time, and physical characteristics of blood vessels might be impacted by risk for Alzheimer's disease. These physiological measures will then be compared to subjects' scores on novel cognitive tests designed to thoroughly characterize memory and hippocampal function.
Rane S, Mason E, Hussey E, Gore J, Ally BA, Donahue MJ; 'The effect of echo time and post-processing procedure on blood oxygenation level-dependent (BOLD) functional connectivity analysis.' Neuroimage. 2014 Mar 25. pii: S1053-8119(14)00216-X. PMID: 24675648
Ko PC, Duda B, Hussey E, Mason E, Molitor RJ, Woodman GF, Ally BA.; 'Understanding age-related reductions in visual working memory capacity: Examining the stages of change detection.' Atten Percept Psychophys. 2014 Jan 14. PMID: 24420648
Donahue MJ, Rane S, Hussey E, Mason E, Pradhan S, Waddell KW, Ally BA.; 'ë_-Aminobutyric acid (GABA) concentration inversely correlates with basal perfusion in human occipital lobe.' J Cereb Blood Flow Metab. 2014 Mar;34(3):532-41. PMID: 24398941