The goal of my research is to lower the number of bone fractures associated with osteoporosis, diabetes, cancer, and aging.
One project investigates the determinants of bound water in bone and the ability of 1H Nuclear Magnetic Resonance to explain the age- and diabetes-related decrease in bone's resistance to fracture. Another project aims to identify novel Raman spectrocospy signatures that can distinguish normal bone quality from poor bone quality. Using wild-type and genetically modified mice with and without exogenous treatments, I also have several projects investigating how advanced glycation end-products, matrix proteins, and growth factors affect bone toughness. In collaboration with my colleagues at the Center for Bone Biology, we test new therapeutics to prevent fractures or heal fractures in pre-clinical rodent models of disease (namely, diabetes, bone metastasis, neurofibromatosis type 1).
Nyman, J.S.*, Gorochow, L. E., Horch, R.A., Uppuganti, S., Zein-Sabatto, A., Manhard, M.K. and M.D. Does. Partial removal of pore and loosely bound water by low-energy drying decreases cortical bone toughness in young and old donors. Journal of the Mechanical Behavior of Biomedical Materials. In press. (http://www.sciencedirect.com/science/article/pii/S1751616112002263)
Lian, N., Lin, T., Liu, W., Wang, W., Li, L., Sun, S., Nyman, J.S. and X. Yang. Transforming Growth Factor Ã?Â² suppresses osteoblast differentiation via vimentin activating transcription factor 4 (ATF4) axis. The Journal of Biological Chemistry. 287:35975-84, 2012.
O'Neill, K.R., Stutz, C.M., Mignemi, N.A., Burns, M.C., Murry, M.R. Nyman, J.S., and J.G. Schoenecker. Micro-computed tomography assessment of the progression of fracture healing in mice bone. Bone. 50:1357-67, 2012.
Horch, R.A., Gochberg, D.F., Nyman, J.S., and M.D. Does. Clinically-compatible MRI strategies for discriminating bound and pore water in cortical bone. Magnetic Resonance in Medicine. 68:1774-84, 2012.
Nyman, J.S.*, Makowski, A.J., Patil, C.A., Masui, T.P., O'Quinn, E.C., Bi, X., Guelcher, S.A., Nicollela, D.P. and A. Mahadevan-Jansen.Â Measuring differences in compositional properties of bone tissue by confocal Raman Spectroscopy. Calcified Tissue International. 89:111-22, 2011.