I am interested in translating quantitative MR techniques to the clinic to better understand the pathological changes associated with neurological diseases such as multiple sclerosis.
My research is focused on developing quantitative MR methodologies including CEST and quantitative magnetization transfer for the brain, spinal cord, and optic nerve.
(Published as K.M. Poole prior to 2016.)
K.P. O'Grady, A.N. Dula, B.D. Lyttle, L.M. Thompson, B.N. Conrad, B.A. Box, L.J. McKeithan, S. Pawate, F. Bagnato, B.A. Landman, P. Newhouse, & S.A. Smith. ?Glutamate-sensitive imaging and evaluation of cognitive impairment in multiple sclerosis.? Multiple Sclerosis Journal. Published (Web): September 19, 2018. NIHMS ID: NIHMS1504330. PMID: 30230400.
K.P. O'Grady, T.E. Kavanaugh, H. Cho, H. Ye, M.K. Gupta, M.C. Madonna, J. Lee, C.M. O?Brien, M.C. Skala, K.A. Hasty, & C.L. Duvall. ?Drug free ROS sponge polymeric microspheres reduce tissue damage from ischemic and mechanical injury.? ACS Biomaterials Science & Engineering 4(4): 1251-1264 (2018).
K.M. Poole, C.E. Nelson, R.V. Joshi, J.R. Martin, M.K. Gupta, S.C. Haws, T.E. Kavanaugh, M.C. Skala, & C.L. Duvall. "ROS-responsive microspheres for on demand antioxidant therapy in a model of diabetic peripheral arterial disease." Biomaterials 41(0): 166-175 (2015) PMC 4274772.
K.M. Poole, D.R. McCormack, C.A. Patil, C.L. Duvall, & M.C. Skala. "Quantifying the vascular response to ischemia with speckle variance optical coherence tomography." Biomedical Optics Express 5(12): 4118-4130 (2014) PMC 4285592.