Vanderbilt University
Institute of Imaging Science
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Manus Donahue, Ph.D.

Associate Professor of Radiology and Radiological Sciences, Psychiatry, Neurology, and Physics and Astronomy
Lab Website

Contact Information

mj.donahue@vumc.org
(615) 322-8350

Interests

To use novel imaging and computational approaches to identify physiological changes that occur prior to advanced symptom progression, and to use these biomarkers to triage patients for disease-modifying therapies prior to irreversible tissue damage.

Projects

1. Quantifying the impact of surgical, pharmacological, and hematopoietic stem cell interventions on tissue health in adult and pediatric patients with cerebrovascular disease
2. Using imaging to guide therapies that improve the lymphatic circulation and lymphoid tissue function in patients with lymphedema, lipedema, and infectious diseases
3. Using deep learning architectures and time-delay analyses to model predictive behavior of dividend growth stock performance
4. Fostering an environment of open communication in clinical radiology departments

Publications

Jordan LC, Gindville MC, Scott AO, Juttukonda MR, Strother MK, Kassim AA, Chen SC, Lu H, Pruthi S, Shyr Y, Donahue MJ. Non-invasive imaging of oxygen extraction fraction in adults with sickle cell anaemia. Brain. 2016 Mar;139(Pt 3):738-50. PMID: 26823369

SPRINT Research Group. A randomized trial of intensive versus standard blood-pressure control. N Engl J Med. 2015 Nov 26;373(22):2103-16. PMID: 26551272

Donahue MJ, Dethrage LM, Faraco CC, Jordan LC, Clemmons P, Singer R, Mocco J, Shyr Y, Desai A, O'Duffy A, Riebau D, Hermann L, Connors J, Kirshner H, Strother MK. Routine clinical evaluation of cerebrovascular reserve capacity using carbogen in patients with intracranial stenosis. Stroke. 2014 Aug;45(8):2335-41. PMID: 24938845

Rane S, Donahue PM, Towse T, Ridner S, Chappell M, Jordi J, Gore J, Donahue MJ. Clinical feasibility of noninvasive visualization of lymphatic flow with principles of spin labeling MR imaging: implications for lymphedema assessment. Radiology. 2013 Dec;269(3):893-902. PMID: 23864103