Vanderbilt University
Institute of Imaging Science
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Natasha Deane, PhD

Research Associate Professor

Contact Information

natasha.deane@vanderbilt.edu
(615) 322-5244

Interests

I study gene expression signatures associated with poor prognosis in colon cancer and basic mechanisms leading to epithelial to mesenchymal transition in colon cancer cells.

Projects

Project 1: determine how Smad4, a tumor suppressor and major mediator of TGF-beta and BMP signaling, regulates epithelial to mesenchymal transitions in colon cancer cells
Project 2: determine the role of four-jointed box (fjx), a Golgi kinase first described in drosophila development, in colon carcinogenesis and tumor progression
Project 3: define and determine the mechanism by which central mediators of gene expression patterns seen in colon cancer regulate metastatic behavior Project 4: develop a prognostic test for stage II and stage III colon cancer based on gene expression profiling

Publications

Yankeelov, TE, Atuegwu, NC, Deane, NG, Gore, JC, Modeling tumor growth and treatment response based on quantitative imaging data, 2010, Integr Biol (Camb.), 2:338. PMID:20596581.

Guo, N., Xie, J., Manning, H. C., Deane, N.G., Ansari, M.S., Coffey, R.J., Gore, J., Price, R.R., Baldwin, R.M., McIntyre, J.O., A Novel In Vitro Assay to Assess Phosphorylation of 3-[(18F)]fluoro-3ª-deoxythymidine, Molecular Imaging Biology, June 2010, (Epub ahead of print),   PMID: 20532643.  

Smith JJ, Deane NG, Wu F, Merchant NB, Zhang B, Jiang A, Lu P, Johnson, JC, Schmidt C, Edwards, CM, Eschrich S, Kis C, Levy S, Washington, MK, Heslin MJ, Coffey RJ, Yeatman TJ, Shyr Y, Beauchamp RD, An experimentally derived metastasis gene expression profile predicts recurrence and death in colon cancer patients, 2010, Gastroenterology 138(3): 958   PMID: 19914252  

Halder, SK, Rachakonda, G, Deane, NG, Datta, PK, Smad7 induces hepatic metastases in colorectal cancer, 2008, British Journal of Cancer 99: 957  PMID: 18781153  

Kanies, CL, Smith, JJ, Kis, C, Schmidt, C., Levy, S., Khabar, KS, Morrow, J, Deane, N, Dixon, DA, Beauchamp, RD, Oncogenic Ras and transforming growth factor beta synergistically regulate AU-rick element containing mRNAs during epithelial to mesenchymal transition, 2008, Molecular Cancer Research, 6: 1124   PMID: 18644977