Richard Dortch, Ph.D.Research Assistant Professor
Radiology and Radiological Sciences
The overall goal of our research is to develop and validate quantitative MRI methods (e.g., magnetization transfer, diffusion, relaxometry) for imaging human spinal cord, optic nerve, and peripheral nerve in vivo. The long-term goal of my work is to apply these methods in clinical patient populations to aid our understanding of diseases that specifically affect these tissues.
Current projects include: 1) characterization of dysmyelination in the proximal nerve of Charcot-Marie-Tooth patients via magnetization transfer imaging of, 2) optimization of quantitative magnetization transfer, diffusion, and T2 imaging for applications in peripheral nerve, 3) development of novel, robust fat suppression strategies, and 4) development of quantitative magnetization transfer imaging of the spinal cord at 7.0 T.
Dortch RD and Does MD. Quantitative Measurement of T1, T2, T2*, and Proton Density. In: Quantitative MRI in Cancer. Yankeelov TE, Pickens III DR, Price RR (Eds.). London: Taylor and Francis Press: 53-66 (2011).
Dortch RD, Li K, Tamhane AA, Welch EB, Gochberg DF, Gore JC, and Smith SA. Quantitative Magnetization Transfer Imaging of Human Brain at 3T via Selective Inversion Recovery. Magn Reson Med 66:1346"1352 (2011).
Dortch RD, Moore JE, Li K, Jankiewicz M, Gochberg DF, Gore JC, and Smith SA. Quantitative Magnetization Transfer Imaging of Human Brain at 7 Tesla. Neuroimage. 64:640"649 (2013).
Dortch RD, Harkins KD, Juttukonda M, Gore JC, and Does MD. Characterizing Inter-compartmental Water Exchange in Myelinated Tissue using Relaxation Exchange Spectroscopy. Magn Reson Med. Available Online.