My group is interested in developing nanostructure-based probes that integrate multiple imaging modalities on a single platform to enable synergistic multimodal multiplexed imaging in mouse models in vivo.
I started the "Nanophotonics and Biophotonics Laboratory" at Vanderbilt University in August 2012 with research efforts focused on designing light manipulating nanostructures with unique properties that enable their use in biomedical imaging, therapeutics, and point-of-care assays. The first theme of our lab focuses on designing nanoprobes for clinical and pre-clinical imaging, and image-guided therapies. In this effort we are interfacing nanostructures with immuno-oncology and combining PET and Raman multimodal multiplexed imaging to detect immunomarkers of cancer, and also monitor response to immunotherapies. Further, we are also using these nanostructures for image-guided light controlled drug delivery, immunotherapies, and combinatorial treatment in mouse models in vivo. A second theme of our lab is focused on Metabolic Raman imaging where we will map metabolic changes in cancer cells and tumor organoids in response to clinically-relevant treatment, and further apply this technique beyond cancer to obesity as well as neurodegenerative diseases. The last theme of our lab also focuses on designing low-cost point-of-care diagnostics with our nanostructures to detect biomarkers of various disorders with sensitivities that surpass current commercial platforms.
Y-C. Ou, E. P. Paul, A. C. Johnson, C. Corn, E. C. Lin, D. Shae, J. N. Bateman, O. Ayala, J. A. Webb, M. Rafat, J. M. Balko, T. Peterson, A. Mahadevan-Jansen, A. E. Vilgelm, R. Bardhan*, "Multimodal Multiplexed Imaging with Gold Nanostars for Detection of Immunomarkers and to Monitor Response to Immunotherapies", to be submitted to Nature Nanotech
Y-C. Ou, J. A. Webb, C. M. O?Brien, I. Pence, E. C. Lin, E. P. Paul, D. Cole, S-H. Ou, M. Lapierre-Landry, E. S. Lippman, A. Mahadevan-Jansen, and R. Bardhan*, "Diagnosis of Immunomarkers in vivo via Multiplexed Surface Enhanced Raman Spectroscopy with Gold Nanostars", Nanoscale, 2018, 10, 13092-13105
J. A. Webb#, Y-C. Ou#, S. Faley, E. P. Paul, J. P. Hittinger, C. C. Cutright, E. C. Lin, L. M. Bellan, and R. Bardhan*, "Theranostic Gold Nanoantennas for Simultaneous Multiplexed Raman Imaging of Immunomarkers and Photothermal Therapy", ACS Omega, 2017, 2, 3583?3594. (# equal contributing first author)
Y-C. Ou, J. A. Webb, S. Faley, D. Shae, E. M. Talbert, S. Lin, C. C. Cutright, J. T. Wilson, L. M. Bellan, and R. Bardhan*, "Gold Nanoantenna Mediated Photothermal Drug Delivery from Thermosensitive Liposomes in Breast Cancer", ACS Omega, 2016, 1, 234?243
J. A. Webb, and R. Bardhan*, "Emerging Advances in Nanomedicine with Engineered Gold Nanostructures" Nanoscale, 2014, 6, 2502-2530