I am interested in applying functional MRI methods to quantify activation and networks across the brain in both healthy and disease states. I use this information to inform presurgical decision making in patients with brain lesions and epilepsy.
I am currently involved in several research projects involving the use of functional MRI (fMRI) to quantify the effects of epilepsy on the brain. Specifically, we are searching for ways to use fMRI to localize the seizure focus and related seizure propagation networks in temporal lobe epilepsy. In addition, we are attempting to relate cognitive and functional changes associated with the disease to the functional network alterations. Other projects include the application of multimodal MRI to concussion, and the investigation of improved functional connectivity techniques.
Holmes MJ, Folley BS, Sonmezturk HH, Gore JC, Kang H, Abou-Khalil B, Morgan VL. Resting state functional connectivity of the hippocampus associated with neurocognitive function in left temporal lobe epilepsy. Human Brain Mapping, 2014;35(3):735-44. PMCID:PMC3915042
Holmes MJ, Yang X, Landman BA, Ding Z, Kang H, Abou-Khalil BA, Sonmezturk HH, Gore JC, Morgan VL. Functional networks in temporal lobe epilepsy: a voxel-wise study of resting-state functional connectivity and gray matter concentration. Brain Connectivity 2013; 3(1):22-30. PMCID:PMC3621340
Ding Z, Newton AT, Xu R, Anderson AW, Morgan VL, Gore JC. Spatio-temporal correlation tensors reveal functional structure in human brain. PLoS ONE 2013; 8(12):e82107.
Morgan VL, Sonmezturk HH, Gore JC, Abou-Khalil B. Lateralization of temporal lobe epilepsy using resting functional Magnetic Resonance Imaging connectivity of hippocampal networks. Epilepsia 2012;53(9):1628-35. PMCID: PMC3436984
Morgan VL, Roger BP, Sonmezturk HH, Gore JC, Abou-Khalil B. Cross hippocampal influence in mesial temporal lobe epilepsy measured with high temporal resolution functional Magnetic Resonance Imaging. Epilepsia 2011;52(9):1741-1749. PMCID in process