Yiu-Yin Cheung, Ph.D.Radiochemist III
My research at the VUIIS focuses on the rational design and synthesis of small molecules as novel ligands for TSPO with the goal of developing them into [18F]-PET tracers to be used for cancer imaging. I am also involved in collaborative projects which require either the radiosynthesis development of novel [18F]-PET tracers or the production of known [18F]-PET tracers such as FLT, FES, F-Choline and SFB for pre-clinical imaging studies.
Cheung, Y. Y.; Yu, H; Xu, K; Zou, B; Wu, M; McManus, O. B.; Li, M; Lindsley, C. W.; Hopkins, C. R. "Discovery of a Series of 2-Phenyl-N-(2-(pyrrolidin-1-yl)phenyl)acetamides as Novel Molecular Switches that Modulate Modes of Kv7.2 (KCNQ2) Channel Pharmacology: Identification of (S)-2-Phenyl-N-(2-(pyrrolidin-1-yl)phenyl)butanamide (ML252) as a Potent, Brain Penetrant Kv7.2 Channel Inhibitor," J. Med. Chem., 2012, 55, 6975-6979.
Melancon, B. J.; Utley, T. J.; Sevel, C; Mattman, M. E.; Cheung, Y. Y.; Bridges, T. M.; Morrison, R. D.; Sheffler, D. J.; Niswender, C. M.; Daniels, J. S.; Conn, P. J.; Lindsley, C. W.; Wood, M. R. "Development of novel M1 antagonist scaffolds through the continued optimization of the MLPCN probe ML012," Bioorg. Med. Chem. Lett. 2012, 22, 5053-5040.
Allard, M; Barnes, K; Chen, X; Cheung, Y. Y., Duff, B; Heap, C; Inthavongsay, J; Johnson, M; Krishnamoorthy, R; Manley, C; Steffke, S; Varughese, D; Wang, R; Wang , Y; Schwartz, C. E. "Total synthesis of Resolvin E1," Tetrahedron Lett. 2011, 52, 2023-2626
Cheung, Y. Y.; Zamorano, R; Blobaum, A. L.; Weaver, C. D.; Conn, P. J.; Lindsley, C. W.; Niswender, C. M.; Hopkins, C. R. "Solution-Phase Parallel Synthesis and SAR of Homopiperazinyl Analogs as Positive Allosteric Modulators of mGlu4," ACS Combi. Sci. 2011, 13, 159-165
Mader, M. M.; Shih, C.; Considine, E.; De Dos, A.; Grossman, C. S.; Hipskind, P. A.; Lin, H-S.; Lobb, K. L.; Lopez, B.; Lopez, J. E.; Cabrejas, L. M. M.; Richett, M. E.; White, W. T.; Cheung, Y. Y.; Huang, Z.; Reilly, J. E.; Dinn, S. R. "Acyl sulfonamide anti-proliferatives. Part 2: Activity of heterocyclic sulfonamide derivatives," Bioorg. Med. Chem. Lett. 2005, 15, 617-620.