The Vanderbilt University Institute of Imaging Science (VUIIS) is a University-wide interdisciplinary initiative that unites scientists whose interests span the spectrum of imaging research—from the underlying physics of imaging techniques to the application of imaging tools to address problems such as understanding brain function. The VUIIS has a core program of research related to developing new imaging technology based on advances in physics, engineering, and computer science. In addition to high-field MRI and MR spectroscopy, ultrasound, optical and other modalities in human subjects, the VUIIS offers state-of-the-art options for small animal imaging in all modalities. In 2007 Vanderbilt completed a four-floor, state-of-the-art facility adjacent to Medical Center North to house the VUIIS. The $28 million project ($21 million for construction) provides a 42,000-square-foot facility to integrate current activities in imaging research and provide research space for 42 faculty members and more than 80 graduate students and postdoctoral fellows in biomedical science, engineering, and physics.